Research has highlighted the potential anti-leukemic role of CD8+ T cells in CLL, demonstrated by clonal expansion in patients and murine models (Hanna et al., 2019; Vardi et al., 2016; Vardi et al., 2017; Blanco et al., 2018; Serrano et al., 1997; Kowalewski et al., 2015). This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.