CD8A and B-cell chronic lymphocytic leukemia: CD8+ T cells exhibit altered differentiation in CLL, favoring antigen-experienced effector and effector memory phenotypes over naïve and central memory phenotypes seen in age-matched healthy donors (Riches et al., 2013; Gamal et al., 2025; McClanahan et al., 2015; Hanna et al., 2019; Tonino et al., 2012; Mackus et al., 2003; Brusa et al., 2013; Göthert et al., 2013; Gonnord et al., 2019).