On the contrary, other studies have reported increased Th1 cells producing IFNγ in CLL patients and Eμ-TCL1 mice, suggesting a role in promoting CLL-cell activation (Podhorecka et al., 2002; Os et al., 2013; Roessner et al., 2020; Bürgler et al., 2015; Zaki et al., 2000). This evidence concerns the gene IFNG and B-cell chronic lymphocytic leukemia.