Elevated expression of GRIN2A was observed in the PVALB_RGS5 subtype, and gain-of-function mutations in GRIN2A are linked to N-methyl-D-aspartate receptor overactivation, neuronal hyperexcitability (Chen et al., 2017) and severe developmental and epileptic encephalopathy phenotypes (Strehlow et al., 2019). Here, GRIN2A is linked to Epileptic encephalopathy.