Important symptoms of Al neurotoxicity, which contributes to the etiology of AD, include Aβ deposition, hyperphosphorylation of tau protein, increased activity of acetylcholinesterase, imbalance in neurotransmitter levels, inflammatory cytokines, mitochondrial damage, oxidative stress, and deficits in memory and learning (Wojtunik-Kulesza et al., 2016; Auti and Kulkarni, 2019). The gene discussed is MAPT; the disease is Alzheimer disease.