For instance, sulforaphane, curcumin, and fucoxanthin inhibit myocardial oxidative damage in type 2 diabetic (T2D) mice by activating nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant gene expression, resulting in reduced myocardial fibrosis, improved cardiac function, and improved DCM symptomatology (Bai et al., 2013; Wu et al., 2022b; Zheng et al., 2022). Here, NFE2L2 is linked to type 2 diabetes mellitus.