Studies have found that A-MG plays a protective role in ischemic heart disease by suppressing oxidative stress and reducing cardiomyocyte apoptosis (Fang et al., 2018), protects the heart from toxic damage caused by doxorubicin (Eisvand et al., 2022), and mediates the significant reduction in systolic and diastolic blood pressure in spontaneously hypertensive rats by downregulating angiotensin II expression (Xu et al., 2024b). Here, AGT is linked to coronary artery disorder.