Both in vitro and in vivo studies by Chen et al. (2023) have shown that non-SMC condensin I complex subunit H (NCAPH) upregulation in ccRCC promotes tumor cell proliferation, CD8+ T cell dysfunction, and programmed death-ligand 1(PD-L1) expression by inhibiting β-catenin degradation, ultimately enhancing aerobic glycolysis and immune tolerance in ccRCC. The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.