METTL3 and nonpapillary renal cell carcinoma: In ccRCC cells, METTL3 knockdown significantly reduces virion production due to its involvement in the m6A modification of the primary viral lytic transactivator open reading frame 50 (ORF50), thereby impeding its post-transcriptional accumulation (METTL3 knockdown ↓ → reduces virion production by destabilizing m6A-modified ORF50 mRNA).