Collectively, METTL3 influences the initiation, progression, metastasis, poor prognosis, and malignancy of ccRCC through various mechanisms, including epithelial-mesenchymal transition (EMT), modulation of inflammatory responses, cell cycle regulation, alterations in glycolytic metabolism, immune evasion and infiltration strategies, and the modulation of cellular biological functions. This evidence concerns the gene METTL3 and nonpapillary renal cell carcinoma.