By regulating key processes such as metabolic reprogramming (e.g., lipid metabolism, glycolysis), immune evasion, and EMT, METTL3 stabilizes pro-tumorigenic transcripts (e.g., HIF-1α, vascular endothelial growth factor [VEGFA]) while destabilizing tumor suppressors (e.g., ZNF677), thereby enabling ccRCC proliferation and invasion. Here, VEGFA is linked to nonpapillary renal cell carcinoma.