Current research on ARHGEF37 is limited, mainly focusing on its role in promoting adhesion and transendothelial migration of tumor cells in hepatocellular carcinoma and enhancing the infiltration and metastatic capabilities of hepatocellular carcinoma (HCC) cells (Zhang et al., 2022); there is a lack of research on other diseases, such as FM. The gene discussed is ARHGEF37; the disease is hepatocellular carcinoma.