NPC1 and neurodegenerative disease: Given the known role of lamin dysfunction in neurodegenerative diseases (Frost et al., 2016; Nguyen et al., 2021), it will be important to explore whether PKCδ-mediated phosphorylation of Lamin A/C contributes to nuclear remodeling and whether other nuclear structural proteins, such as nuclear pore complex (NPC) and inner nuclear membrane (INM) proteins, play a role in maintaining nuclear integrity under mitochondrial stress.