Current guidelines from GINA and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) primarily rely on clinical data for managing asthma, COPD, and ACO, including spirometry and a few biomarkers such as blood and sputum eosinophils, IgE, and the fractional exhaled nitric oxide test (FeNO). Here, IGHE is linked to chronic obstructive pulmonary disease.