SHANK3 and premenstrual tension: Due to the prevalence of GI symptoms in PMS, the impact of Shank3 mutations on the intestinal microbiome, alongside histological characterization of the small intestine, has previously been studied in murine knockout (KO) models (Tabouy et al., 2018; Sauer et al., 2019; Delling and Boeckers, 2021; Wong et al., 2021).