The accumulation of visceral fat, a typical symptom of obesity, leads to the production of adipokines such as leptin (8), lipocalin (9), C1q tumor necrosis factor-related protein 9 (10), chemerin (11), and retinol-binding protein 4 (12), which are involved in a variety of metabolic processes such as glucose uptake, insulin signaling, and fatty acid oxidation, and are highly correlated with T2DM and cardiovascular and microvascular complications are highly relevant (13, 14). This evidence concerns the gene INS and obesity disorder.