PLA2G7 and brain infarction: Additionally, prolonged hyperglycemia can lead to microvascular complications, such as retinopathy, nephropathy, and neuropathy, which may impair cerebral blood supply and further increase the risk of cerebral infarction (4) Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in plasma have been proposed as a biomarker for predicting AIS risk (5).