For instance, NLRP3 inflammasome knockout in endothelial progenitor cells (EPCs) was reported to rescue angiogenesis in diabetic mice with myocardial infarction, suggesting that the PI3K/AKT/mTOR cascade acts as a downstream effector of NLRP3-mediated inflammatory responses (31). This evidence concerns the gene AKT1 and myocardial infarction.