Genetic mutations contribute to 30-40% of dilated cardiomyopathy (DCM) and HCM cases, with titin truncating variant (TTNtv), myosin-binding protein C3 (MYBPC3), lamin A/C gene (LMNA) and BCL2-associated athanogene-3 (BAG3) among the most common pathogenic variants. The gene discussed is MYBPC3; the disease is dilated cardiomyopathy.