Our study identifies that dysregulation in genes like NOS3, TNF, BDNF, ESR1, ESR2, LMX1B, ATP1A2, OPRM1, NPY, THRB, NRXN3, SPARC, and MYT1l significantly impacts the interplay between obesity and chronic pain. The gene discussed is OPRM1; the disease is obesity due to melanocortin 4 receptor deficiency.