We have demonstrated the allosteric interaction of HIV-Tat protein with the dopamine transporter (DAT), norepinephrine (NET), and serotonin transporter (SERT) as the main mechanism to disrupt the monoaminergic transmission in HIV infection, which a novel allosteric modulator, SRI-32743, can attenuate. The gene discussed is SLC6A4; the disease is HIV infectious disease.