BACE1 and Alzheimer disease: Using SH-SY5Y human neuroblastoma cells, we determined the effects of clinically relevant concentrations of three BACE-1 inhibitors (elenbecestat, lanabecestat and verubecestat) and two non-BACE-1 anti-AD drugs (memantine and galanthamine) on endolysosome and mitochondrial stress responses.