Bioinformatic analysis identified key pathways (Serotonin Receptor Signaling, Dopamine-DARPP32 Feedback in cAMP Signaling, Acetylcholine Receptor Signaling Pathway, and Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity) related to increased anxiety and impaired locomotion in BE-treated young adult mice. The gene discussed is PPP1R1B; the disease is Barrett esophagus.