CASP3, CNR1, CXADR, FMR1, FTO, HOMER1, KCNQ2, SLC12A2 were upregulated and BCL2, BDNF, CDKSR1, KMT2A, LONP1, MTOR, PPME1, VEGFD, and VWF were downregulated to mediate the activation of cognitive impairment (Figure 7A). This evidence concerns the gene VWF and Cognitive impairment.