CASP3, CNR1, CXADR, FMR1, FTO, HOMER1, KCNQ2, SLC12A2 were upregulated and BCL2, BDNF, CDKSR1, KMT2A, LONP1, MTOR, PPME1, VEGFD, and VWF were downregulated to mediate the activation of cognitive impairment (Figure 7A). The gene discussed is LONP1; the disease is Cognitive impairment.