TLR4 and neoplasm: Calreticulin, ATP, and HMGB1 bind to CD91, P2RX7, and TLR4, respectively, facilitating dendritic cell (DC) recruitment into the tumor bed (by ATP), the phagocytosis of tumor antigens by DCs (enhanced by CRT), and an optimal antigen presentation to T cells (stimulated by calreticulin and HMGB1).