Several studies have suggested that a loss of IRP2 may increase the risk of neurodegenerative diseases by affecting mitochondrial function, promoting oxidative stress, and interfering with the synthesis of neurotransmitters and the maintenance of myelin (Chen et al., 2020; Shen et al., 2021; Porras et al., 2024). This evidence concerns the gene IREB2 and neurodegenerative disease.