By binding to the IRE structure in p53 mRNA, IRP2 post-transcriptionally upregulates p53 expression, resulting in the downregulation of SLC7A11 and GPX4, increasing lipid peroxidation levels, inducing iron death, and further exacerbating PD pathology (Chang et al., 2023; Li et al., 2024). This evidence concerns the gene GPX4 and Parkinson disease.