JOURNAL/nrgr/04.03/01300535-202606000-00068/figure1/v/2026-02-11T151048Z/r/image-tiff Alzheimer's disease is initially thought to be caused by age-associated accumulation of plaques, in recent years, research has increasingly associated Alzheimer's disease with lysosomal storage and metabolic disorders, and the explanation of its pathogenesis has shifted from amyloid and tau accumulation to oxidative stress and impaired lipid and glucose metabolism aggravated by hypoxic conditions. This evidence concerns the gene MAPT and Alzheimer disease.