Therefore, we can hypothesize that under cerebral ischemia, the BDNF promoter IV may be damaged, not only affecting the normal process of synaptic pruning but also potentially causing a reduction in GABAergic synapses (Xu et al., 2023b), further exacerbating the neuronal damage caused by cerebral ischemia. The gene discussed is BDNF; the disease is Cerebral ischemia.