Methylation of CDH1 and concomitantly reduced cadherin-E expression has been reported to increase the recurrence rates and invasive potentials of breast cancer and glioblastoma, leading to poorer prognosis.41-43 The NFKB1 gene encodes a member of the nuclear factor-kappa B (NF-κB) family of stress-responsive transcription factors. This evidence concerns the gene CDH1 and breast carcinoma.