38 Once HIF-1 enters the nucleus, it activates the transcription of over a hundred target genes, including genes involved in angiogenesis, invasion, glucose metabolism, and lipid metabolism.39,40 Thus, suppression of HIF-1 transactivation activity by vortioxetine may enhance hypoxic death of glioblastoma cells and thereby limit disease progression. This evidence concerns the gene HIF1A and glioblastoma.