HIF1A and glioblastoma: Glucose metabolism is essential for cell migration and thus for glioblastoma invasiveness.46 Furthermore, programmed cell death alters the inflammatory tumor microenvironment and facilitates glioblastoma progression.47 Kyoto Encyclopedia of Genes and Genomes pathway analyses identified Rap1, chemical carcinogenesis-ROS, and HIF-1 signaling as major pathways linking vortioxetine binding to glioblastoma.