The long non-coding RNA LBX2-AS1 activates the proinflammatory interleukin-4 receptor by binding to NFKB1, which in turn enhances glioblastoma metastasis and angiogenesis.45 Thus, these core targets can all modulate the risk of glioblastoma through distinct mechanisms. This evidence concerns the gene LBX2 and glioblastoma.