AKT3 and glioblastoma: The AKTs are a family of 3 serine/threonine kinases (AKT1, AKT2, and AKT3) with numerous protein targets and diverse functions in cell proliferation, survival, migration, and metabolism.32,33 Overexpression of AKT1 is frequently observed in breast cancer, liver cancer, and glioblastoma,34-36 and higher overexpression has been reported in glioblastoma patients with poorest prognosis.35,37 Although glioblastoma is one of the most vascularized tumors in humans, the microcirculation is highly inefficient, leading to areas of severe hypoxia and necrosis.