54 SNPs and 41 indels of prominent variations were detected;A higher count of SNPs was particularly detected in patients with older age, larger tumor, and metastatic disease;CTNNB1 mutations occur in all patients, which might collaborate with other events such as variations of USP9X, EP400, HTT, MED12, and PKD1 to regulate tumorigenesis. Here, EP400 is linked to metastatic neoplasm.