MED12 and metastatic neoplasm: 54 SNPs and 41 indels of prominent variations were detected;A higher count of SNPs was particularly detected in patients with older age, larger tumor, and metastatic disease;CTNNB1 mutations occur in all patients, which might collaborate with other events such as variations of USP9X, EP400, HTT, MED12, and PKD1 to regulate tumorigenesis.