ACTA2 and breast cancer: This set comprised senescence markers (CDKN1A, LMNB1, MKI67), apoptosis regulators (BCL2, BCL2L1), a highly overexpressed gene (ITGB6), and drug targets (ACTA2, GSDMC, KRT6A, PDE1A, PSMA8), all of which showed strong concordance with our RNA-seq data in all four breast cancer cell lines.