Furthermore, we found that FBL [65], NME2 [66], FLNA [67], ENO1 [68, 69] and ANXA2 [70, 71] were described in a recently identified set of SASP proteins, found in irradiated, RAS-transformed and atazanavir treated senescent fibroblasts, further strengthening the similarity between TIS in cancer cells and TIS and OIS in healthy cells [65]. This evidence concerns the gene ANXA2 and cancer.