Although such infiltration is characteristic of RCRC generally [67], other RCRC-associated traits, such as high expression of immune checkpoint markers [66], were similarly observed in high HOXC6-expressing glioma cells, which, strikingly, suggests that HOXC6 may be supporting the aggressive pathogenesis of RCRC through pan-cancer mechanisms [63]. Here, HOXC6 is linked to central nervous system cancer.