HOXC6 and colorectal carcinoma: In cervical cancer, experimental silencing of HOXC6 with small interfering RNA (siRNA) was seen to inhibit EMT through the TGF-b signaling pathway [62], however in CRC, HOXC6-related proliferation [63] and EMT [64] were found to require mTOR and Wnt signaling, respectively, suggesting a multifaceted, and potentially plastic, role of HOXC6 in disease progression.