In the study by Wong et al. [10], where the authors compared 15 PTCs with high-grade features (PTC-HGF) and 47 PDTCs cases, the authors report higher rates of pT4 disease and lymph node metastasis in PTC-HGF vs. PDTC, indicating that PTC-HGF can present more aggressive pathological profile than PDTC. Here, HGF is linked to metastatic malignant neoplasm in the lymph nodes.