Furthermore, through CIBERSORT-based deconvolution with public bulk transcriptome data from three immunotherapy cohorts, including bladder cancer (BLCA), melanoma, and gastric cancer (STAD)36,37, the proportions of CD8+ effector/memory T cells and CD4+ memory T cells correlated with favorable prognosis and were enriched in responders (Supplementary Fig. 3d–f). This evidence concerns the gene CD4 and bladder transitional cell carcinoma.