In the dermis of lesional punch biopsies from patients with AD at baseline and week 12 (Fig. 6), the percentage of cells staining for GATA3 was positively correlated with cells staining for CD3 (Pearson r = 0.7546, p < 0.0001; Supplementary Fig. 6), suggesting the presence of Th2 cells within this compartment. The gene discussed is GATA3; the disease is Alzheimer disease.