Interestingly, COL7A1 mRNA expression has also been demonstrated to be triggered by TGF-β1 in primary ATII cells, as well as by a fibrosis cocktail (containing TGF-β1 and other IPF-relevant cytokines) in ATII cells derived from human induced pluripotent stem cells.45 This evidence concerns the gene TGFB1 and fibrosis.