ChREBP has roles in lipid metabolism, gluconeogenesis, fructolysis, and glucose-stimulated insulin secretion, all adding to its involvement in NAFLD development in response to carbohydrates (10, 11, 12, 13, 14, 15, 16, 17, 18, 19). The gene discussed is MLXIPL; the disease is metabolic dysfunction-associated steatotic liver disease.