These pathways were all downregulated in spring and included pathways in cancer (4.5-fold enrichment, p<0.001), transcriptional misregulation in cancer (8.3-fold enrichment, p<0.001), fluid shear stress and atherosclerosis (9.5-fold enrichment, p<0.01), small cell lung cancer (11.5-fold enrichment, p<0.01), IL-17 signaling (11.3-fold enrichment, p<0.01), cAMP signaling (5.9-fold enrichment, p<0.01), and apoptosis (7.8-fold enrichment, p<0.05) (Figure 2B). Here, IL17A is linked to atherosclerosis.