CCDC22 and cancer: The four genes that overlap between both analyses include Figure 4: CCDC22, which plays an important role in endosomal recycling of membrane proteins (Singla et al., 2019); LMX1A, a transcription factor essential for dopaminergic neuron development Hoekstra et al., 2013; KCNS1, which encodes a subunit of potassium channels associated with neuronal excitability and pain sensitivity Tsantoulas et al., 2018; and PAQR4, which appears to regulate growth and apoptosis through sphingolipid synthesis in human cancers (Pedersen et al., 2020).