Pathways in cancer consisted of nine significantly downregulated genes (from DESeq2 Wald test), four of which overlapped with apoptotic pathways including BCL2L1 (–0.6 log-fold change [LFC] padj<0.01), NFKBIA (–1.3 LFC, padj<0.01), FOS (–1.5 LFC, padj<0.05), and GADD45B (–1.4 LFC, padj<0.05) (Figure 2C). This evidence concerns the gene GADD45B and cancer.