The primary features identified included age, N-terminal pro-brain natriuretic peptide, fasting blood glucose, triglyceride/high-density lipoprotein cholesterol ratio, triglyceride glucose index, triglyceride glucose-BMI index, atherogenic index of plasma index, and Apolipoprotein B. Among the 5 models, the support vector machine demonstrated the best predictive performance for major adverse cardiovascular and cerebrovascular events in patients with severe AS and HFpEF following TAVR, achieving an area under the curve of 0.756 (95% CI 0.631-0.881) in the independent validation set. This evidence concerns the gene APOB and aortic stenosis.