Mounting evidence highlight the protective role of PRX2, a downstream mediator of Nrf2, in eliminating peroxides and inhibiting apoptosis in different disease models, including traumatic brain injury (Zhang et al. 2021), ischemic injury (Leak et al. 2013), Parkinson’s disease (Hu et al. 2011), and subarachnoid hemorrhage (Lu et al. 2019). This evidence concerns the gene NFE2L2 and brain injury.