Mounting evidence highlight the protective role of PRX2, a downstream mediator of Nrf2, in eliminating peroxides and inhibiting apoptosis in different disease models, including traumatic brain injury (Zhang et al. 2021), ischemic injury (Leak et al. 2013), Parkinson’s disease (Hu et al. 2011), and subarachnoid hemorrhage (Lu et al. 2019). The gene discussed is NFE2L2; the disease is Parkinson disease.