In this context, Liu et al. combined first- and second-order radiomic features extracted from T2-weighted fat-sat images, post-contrast MR arterial, portal venous and delayed phases of dynamic imaging with clinical parameters (e.g., CEA, CA 19-9, AFP, age, sex and vascular factors) to develop a robust hybrid radiomic with an AUC = 0.877 in differentiating ICC from HCC in the validation set [101]. The gene discussed is AFP; the disease is intrahepatic cholangiocarcinoma.