Because of its close histological relationship to malignant melanoma (presence of melanin, ultrastructural evidence of melanosomes, and immunohistochemical staining for the S-100 protein and the melanoma-associated antigen HMB-45), Chung and Enzinger proposed the name malignant melanoma of the soft tissue [2,4,5,6]. The gene discussed is PMEL; the disease is melanoma.