CD300LF and Splenomegaly: Of note, the development of splenomegaly (represented by an increase in spleen weight) and consequently bacterial loads within the spleens were significantly elevated in rickettsiae-infected Cl2MBP-treated mice as compared to that of bacteria-infected PBS-liposomes-treated WT and CD300f-/- animals (Fig. 5C and D, F and G).