GH1 and juvenile idiopathic arthritis: Saha et al. in a randomized controlled trial involving 25 prepubertal children who experienced severe growth delay due to JIA treated with rhGH for 6 months, followed by a 6-month placebo phase, showed a significant growth improvement during the rhGH treatment (the median HSDS was +2.09 during GH treatment, and −1.11 during placebo treatment) [81].