Regional variations in MetS prevalence are evident, with higher rates in Asian populations, potentially due to physiological traits such as increased abdominal adiposity, dietary patterns high in refined carbohydrates and saturated fats, and genetic predispositions, including apolipoprotein A1 (APOA1) polymorphisms [34,35,36]—Table 2. The gene discussed is APOA1; the disease is metabolic syndrome.