GH1 and hypopituitarism: Hypoglycemia associated with GHD is often an exacerbation of complex genetic defects or anatomical alterations of the hypothalamic–pituitary axis [9,10,11]; in a cohort of patients with hypoglycemia treated with growth hormone due to the suspicion of hypopituitarism, it was found that structural lesions of the hypothalamic–pituitary area or midline anatomical facial defects were present in approximately one-third of the neonates [6].