Third, both augmented Panx1 channel expression and elevated levels of lysophospholipids have been independently reported to be associated with insulin resistance (Law et al., 2019; Tozzi et al., 2020), a common health problem linked to a wide array of pathologic conditions, including type 2 diabetes, hypertension, and atherosclerosis. Here, PANX1 is linked to type 2 diabetes mellitus.