Although it has no specific application for PD, a study investigating the ability of orexin A to modulate mesolimbic dopamine transmission during feeding showed that lactoferrin-conjugated liposomes with orexin A enhanced dopamine release in the nucleus accumbens shell and facilitated orexin A delivery to the central nervous system, improving its bioavailability and therapeutic potential, as this peptide is large and does not cross alone the BBB [157]. Here, HCRT is linked to Parkinson disease.