Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography/tandem mass spectrometry (LC-MS/MS) were used [77], revealing a significant increase in AQEE-10 peptide in patients affected by C9-ALS (n = 16) compared to C9-FTD patients (n = 9). This evidence concerns the gene C9 and frontotemporal dementia.