For example, subject 4 with mild liver injury at baseline (Supplemental Figure 2A) experienced an 11% weight loss, which was associated with a doubling of insulin sensitivity and reductions in alanine transaminase (–83%), plasma TGs (–50%), and liver fat (27.3% to 1.8%, assessed by magnetic resonance spectroscopy [MRS]) along with histological evidence of resolution of steatosis and fibrosis. The gene discussed is INS; the disease is steatosis.