C5AR2 and colorectal cancer: In lung and breast cancer, C5AR2 together with IL-10 were robustly associated with chemoresistance (125); conversely, in a melanoma-bearing murine model, C5AR2 appeared to restrict tumor growth (126), and absence of C5AR2 increased tumor progression in azoxymethane/dextran sodium sulfate–induced (AOM/DSS-induced) colorectal cancer (CRC) tumorigenesis (a model of colitis-associated cancer), indicating that C5AR2 has an antiinflammatory effect (127).