HAMP and anemia (phenotype): Elevated serum CRP levels represent the presence of inflammatory response in patients, and the tendency to anemia may be due to the fact that most patients with iMCD also have elevated expression of serum IL-6 in inflammatory states, which has been found to be a major inducer of the production of hepcidin, a key regulator of iron homeostasis in vivo, and whose increase is associated with inflammatory anemia (19).