Additionally, VD3 is a potent antioxidant that improves mitochondrial activity while preventing OS‐related protein oxidation, lipid peroxidation (LOP), and DNA damage [17] In this regard, VD3 supplementation has been proposed as a potential intervention to lower diabetes risk and its complications [18]Thus, the present study was conducted to investigate the effect of VD3 on oxidative stress markers and NLRP3 gene expression in patients with T2DM. This evidence concerns the gene NLRP3 and diabetes mellitus.