Additionally, VD3 is a potent antioxidant that improves mitochondrial activity while preventing OS‐related protein oxidation, lipid peroxidation (LOP), and DNA damage [17] In this regard, VD3 supplementation has been proposed as a potential intervention to lower diabetes risk and its complications [18]Thus, the present study was conducted to investigate the effect of VD3 on oxidative stress markers and NLRP3 gene expression in patients with T2DM. The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.