In addition, triggering of the inflammatory cascade following the activation of NLRP3 (Nod‐Like‐Receptor‐Protein‐3) inflammasome, in response to chronic inflammatory conditions such as diabetes and atherosclerosis also has been known to up‐regulate plasma CRP levels [58], via triggering a central cascade of inflammatory signaling represented by interleukin (IL)‐1 β, IL‐6, and CRP [59, 60]. The gene discussed is CRP; the disease is diabetes mellitus.