However, subsequent findings revealed that one of these patients carried a C9ORF72 repeat expansion, which further weakens the evidence linking SIGMAR1 to ALS, suggesting that the association between SIGMAR1 mutations and familial ALS may be coincidental (Luty et al., 2010; Dobson-Stone et al., 2013; Pickering-Brown and Hardy, 2015). Here, SIGMAR1 is linked to amyotrophic lateral sclerosis.