The dysregulation of the m6A machinery, exemplified by deficiencies in YTH N6-methyladenosine RNA-binding protein F1 (YTHDF1) or the upregulation of circRNA regulating synaptic be exocytosis 2 (circRIMS2), exacerbates hippocampal synaptic defects and cognitive impairments in AD models (Shi et al., 2018; Wang X. et al., 2023). This evidence concerns the gene YTHDF1 and Alzheimer disease.