Besides, experiments demonstrated that compared with wild-type mice, BST1 knockout (BST1–/–) mice exhibited anxiety-related symptoms, depression-like behaviors, and impaired social interaction similar to those observed in PD patients, suggesting a potential role of BST1 in pre-motor symptoms of PD (Kasai et al., 2017; Lopatina et al., 2014). This evidence concerns the gene BST1 and depressive disorder.