This is achieved through downregulation of β-catenin transcription factor-7-like-2 (TCF7L2) mRNA and suppression of downstream Wnt/β-catenin signaling target genes, including Cyclin D1, c-Myc, Snail, Vimentin, matrix metalloproteinase 2 (MMP2), and MMP9, in human CRC cells (Pooja et al., 2014). The gene discussed is CCND1; the disease is colorectal carcinoma.